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Saturday, June 25, 2022

Vitamin D linked to dementia

A world-first genetic study from the University of South Australia has suggested a significant link between a lack of vitamin D and the onset of dementia.

Investigating the association between vitamin D, neuroimaging features, and the risk of dementia and stroke, the study found that low levels of vitamin D were associated with lower brain volumes and an increased risk of dementia and stroke.

Dementia is a chronic or progressive syndrome that leads to deterioration in cognitive function. About 487,500 Australians live with dementia and it is the country’s second leading cause of death. Globally, more than 55 million people have dementia with 10 million new cases diagnosed every year.

Supported by the National Health and Medical Research Council, the genetic study analysed data from 294,514 participants from the UK Biobank, examining the impact of low levels of vitamin D (25 nmol/L) and the risk of dementia and stroke.

Nonlinear Mendelian randomisation (MR) – a method of using measured variation in genes to examine the causal effect of a modifiable exposure on disease – were used to test for underlying causality for neuroimaging outcomes, dementia, and stroke.

Senior investigator and Director of UniSA’s Australian Centre for Precision Health, Professor Elina Hyppönen, says the findings are important for the prevention of dementia and appreciating the need to address vitamin D deficiency.

“Vitamin D is a hormone precursor that is increasingly recognised for widespread effects, including on brain health, but until now it has been very difficult to examine what would happen if we were able to prevent vitamin D deficiency,” Prof Hyppönen says.

“Our study is the first to examine the effect of very low levels of vitamin D on the risks of dementia and stroke, using robust genetic analyses among a large population.

“In some contexts, where vitamin D deficiency is relatively common, our findings have important implications for dementia risks. Indeed, in this UK population we observed that up to 17% of dementia cases might have been avoided by boosting vitamin D levels to be within a normal range.”

UniSA says the findings are significant given the high prevalence of dementia around the world.

“Dementia is a progressive and debilitating disease that can devastate individuals and families alike,” Prof Hyppönen says.

“If we’re able to change this reality through ensuring that none of us is severely vitamin D deficient, it would also have further benefits and we could change the health and wellbeing for thousands.

“Most of us are likely to be ok, but for anyone who for whatever reason may not receive enough vitamin D from the sun, modifications to diet may not be enough, and supplementation may well be needed.”

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