Wednesday, April 24, 2024

Trial finds supplement ‘cocktail’ boosts cognitive function in Alzheimer’s patients

A first-of-its-kind human clinical study in Alzheimer’s disease patients has found that a supplement ‘cocktail’ significantly improved cognitive function and associated biomarkers of the disease.

ChromaDex Corp, a global bioscience company, last week announced the promising findings from its clinical study.

The study was a randomised, double-blinded, placebo-controlled human phase II study of 60 patients.

It was part of the ChromaDex External Research Program (CERP™) and investigated a combined metabolic activator (CMA), or ingredient ‘cocktail’, featuring the company’s proprietary Niagen® ingredient (patented nicotinamide riboside or NR) in addition to L-carnitine tartrate, serine, and N-acetyl-L-cysteine (NAC) in 60 mild-to-moderate patients with Alzheimer’s disease.

Results demonstrated CMA supplementation significantly improved cognitive function by 29% (vs only 14% in the Placebo group) and markers of liver and kidney health in Alzheimer’s patients compared to Placebo after 84 days of supplementation.

The study marks an important research milestone, as it is the first-ever peer-reviewed clinical study to investigate the effects of CMA supplementation in human Alzheimer’s patients.

Each CMA dose in the trial consisted of 1g NR, 3.73g L-carnitine tartrate, 12.35g serine, and 2.55g NAC. All patients received one dose per day during the first 28 days and received two doses per day until Day 84.

The trial, reported in the peer-reviewed journal Translational Neurodegeneration, was conducted by a team of scientists, led by Dr Adil Mardinoglu, Professor of Systems Biology in the Science for Life Laboratory at the Royal Institute of Technology (KTH), Stockholm, Sweden ​​and Centre for Host-Microbiome Interaction at the King’s College London, UK.

The use of this CMA builds on previous successful clinical and preclinical studies, which demonstrated CMA effectiveness. In a preclinical study, Alzheimer’s and Parkinson’s disease (PD) rat models were used to demonstrate CMA supplementation resulted in improved brain and liver metabolism. Further, results revealed that hyperemia (blood flow), degeneration (loss of nerve structure or function) and necrosis (death of neurons) in brain neurons were improved by CMA administration in both AD and PD animal models (Science Direct).

In two earlier human clinical trials, CMA supplementation improved liver health in patients with nonalcoholic fatty liver disease (NAFLD) and improved recovery time of patients with COVID-19 (Molecular Systems BiologyAdvanced Science).

In both clinical trials, the success of the CMA was partly attributed to its beneficial effect on mitochondrial health and function.

“Alzheimer’s is a neurodegenerative disease that affects more than 44 million people worldwide,” said Dr Andrew Shao, ChromaDex Senior Vice President of Global Scientific & Regulatory Affairs.

“The encouraging results of this study will pave the way for future human clinical trials investigating CMA as a potential therapeutic strategy for Alzheimer’s disease patients and we look forward to supporting this research.”

He said several risk factors are associated with Alzheimer’s disease including age, poor lifestyle, genetic mutations, and metabolic dysfunction. Although the exact mechanism of the development of Alzheimer’s remains unknown, a large body of evidence suggests that dysfunctional mitochondria and brain energy metabolism may play key roles in its development.

Because mitochondria are critical for cellular energy production, significant changes in mitochondrial function are linked to energy failure and brain cell death. In fact, research suggests optimal mitochondrial health not only helps support brain cell activity by providing cells with sufficient energy, but also protects them by mitigating oxidative stress (a disturbance in the balance between the production of reactive oxygen species, or free radicals, and antioxidant defenses) and damage. Therefore, Dr Adil Mardinoglu’s team sought to determine if supporting mitochondrial function may be an effective strategy in helping improve the symptoms observed in Alzheimer’s disease patients.

“The promising results showcased that activation of mitochondria with the administration of CMA led to improved cognitive functions in AD patients,” Dr Mardinoglu said.

“Further research to determine if CMA improves metabolic abnormalities and cognitive functions in Alzheimer’s disease patients is warranted and we look forward to initiating a Phase 3 study in the near future.”

For additional information on the science supporting Niagen® visit www.chromadex.com.

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